The increasing technological sophistication of hospital care has led to greater appreciation of the potential safety hazards posed by medical devices. Such injuries have been studied in adult inpatients, but this study represents the first population-based estimate of harm caused by medical devices in hospitalized children. Using an administrative database, the investigators found that approximately 1 in 300 pediatric inpatients experienced a device-related injury. Prior research using voluntarily reported data has shown that device injuries are among the most common types of preventable harm in pediatric hospitals. An AHRQ WebM&M commentary discusses the consequences of a central venous catheter–associated complication in a hospitalized infant.