In 2011, the World Health Organization (WHO) created a multi-professional patient safety curriculum guide for training health professionals across the world. This study describes the results of field testing of this curriculum in 12 participating schools across the 6 WHO regions. The guide was well liked by participants and stakeholders and was associated with improvements in student attitudes regarding patient safety. Student knowledge also improved significantly, but overall scores were still quite poor (20.8% correct answers on the post-test versus 10.7% on the pre-test).