Delayed diagnosis of infectious disease can negatively affect patients, care teams, and public health. Challenges surrounding diagnosis of the first Ebola case in the United States highlighted deficits in disaster preparedness. Reviewing insights from a panel analysis of this well-known and highly publicized case of Ebola, this report underscores the need to improve information transfer and emergency department safety culture to enhance diagnostic and infection prevention processes. A previous WebM&M commentary discussed the utility of simulation training to ensure provider competency when caring for patients potentially infected with Ebola.