Burnout may adversely affect patient safety as well as physician wellness. While health care organizations are increasingly focused on measuring burnout and implementing targeted interventions for improvement, the financial costs associated with physician burnout are not well described. In this study, researchers estimate that in the United States, $4.6 billion in costs are incurred from physician turnover and reduced work hours related to burnout on an annual basis. They estimate that the cost for organizations is about $7600 per physician each year. These findings suggest that physician burnout is associated with substantial economic burden. An Annual Perspective discussed burnout and its effect on patient safety.