Medication reconciliation—the process of cross-checking patients' medication lists to correct errors and inadvertent omissions—was named a National Patient Safety Goal in 2005. Despite this, no consensus exists yet as to the best method of accomplishing medication reconciliation. This description of the process of implementing medication reconciliation at an urban public hospital includes much information that will be helpful for hospitals undertaking a similar process. The authors detail the barriers faced in developing the system (which was incorporated into an existing computerized order entry system), encouraging use of the system, and improving it based on user feedback. Prior research in this area has demonstrated the effectiveness of pharmacists at carrying out medication reconciliation.