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Journal Article > Review
A systematic review of the performance characteristics of clinical event monitor signals used to detect adverse drug events in the hospital setting.
Handler SM, Altman RL, Perera S, et al. J Am Med Inform Assoc. 2007;14:451-458.
The authors analyzed the literature and identified laboratory and pharmacy triggers used to detect adverse drug events (ADE) in hospitalized adults and calculated estimates of positive predictive values for individual signals.
Journal Article > Commentary
Information technology-based approaches to reducing repeat drug exposure in patients with known drug allergies.
Cresswell KM, Sheikh A. J Allergy Clin Immunol. 2008;121:1112-1117.e7.
This article analyzes how technology such as barcoding, RFID (radiofrequency identification), and computerized alerts can prevent administration errors in patients with identified medication allergies.
Journal Article > Study
Time-dependent drug–drug interaction alerts in care provider order entry: software may inhibit medication error reductions.
van der Sijs H, Lammers L, van den Tweel A, et al. J Am Med Inform Assoc. 2009;16:864-868.
Alerts within a computerized provider order entry system were not able to prevent medication errors resulting from drug–drug interactions. The authors hypothesize that the inadequacy of the alerts themselves was responsible for this failure, with problems including an excessive number of false-positive alerts and unclear instructions for preventing drug interactions.
ISMP Medication Safety Alert! Acute Care Edition. May 5, 2011;16:1-3.
Journal Article > Study
Potential safety gaps in order entry and automated drug alerts: a nationwide survey of VA physician self-reported practices with computerized order entry.
Spina JR, Glassman PA, Simon B, et al. Med Care. 2011;49:904-910.
In contrast to most hospitals and clinics, the Veterans Affairs (VA) health care system has had a fully electronic health record with computerized provider order entry for several years. In this survey, VA physicians generally had positive impressions of the system, with nearly 90% feeling the system improved drug safety and nearly half reporting that serious drug interaction warnings were "very useful." However, the accuracy of drug–drug interaction and allergy warnings within this system are partially dependent upon clinicians manually entering medications prescribed by non-VA providers. As more than one quarter of respondents admitted to not always entering this data, this study highlights the importance of medication reconciliation in establishing accurate medication lists in the ambulatory care setting.