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Journal Article > Commentary
De Oliveira GS Jr, Theilken LS, McCarthy RJ. Anesth Analg. 2011;113:1429-1435.
Several commonly used anesthesia medications are among the 140 medications currently considered to be in short supply. Data from MEDMARX reveals that shortages have been implicated in many cases of prescribing errors, often when one concentration of medication was substituted for the unavailable formulation.
Journal Article > Study
Impact of a drug shortage on medication errors and clinical outcomes in the pediatric intensive care unit.
Hughes KM, Goswami ES, Morris JL. J Pediatr Pharmacol Ther. 2015;20:453-461.
Drug shortages can result in safety consequences, as studies have shown a higher rate of treatment failure and increased adverse events associated with unavailability of first-line therapies. However, this study did not find any change in adverse events in pediatric intensive care unit patients during a shortage of commonly used sedatives and injectable opioid pain medications. The authors note that advance warning of the shortage and development of standardized algorithms for drug substitution may have mitigated the potential safety hazards.