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Journal Article > Review
Impact of commercial computerized provider order entry (CPOE) and clinical decision support systems (CDSSs) on medication errors, length of stay, and mortality in intensive care units: a systematic review and meta-analysis.
Prgomet M, Li L, Niazkhani Z, Georgiou A, Westbrook JI. J Am Med Inform Assoc. 2017;24:413-422.
While prior research has shown that computerized provider order entry and clinical decision support systems have the potential to improve patient safety, less is known about the impact of such systems in intensive care units. In this systematic review and meta-analysis, investigators found an 85% decrease in prescribing errors and a 12% reduction in ICU mortality rates in critical care units that converted from paper orders to commercially available computerized provider order entry systems.
Journal Article > Study
Evaluation of medication-related clinical decision support alert overrides in the intensive care unit.
Wong A, Amato MG, Seger DL, et al. J Crit Care. 2017;39:156-161.
This retrospective study reviewed more than 47,000 overridden medication alerts and found that the vast majority of overrides were clinically appropriate and did not cause harm. From this sample, 7 adverse drug events were identified, and these events were more likely when the alerts were overridden in error. This study demonstrates the challenge of identifying clinically important alerts in a setting where alert fatigue is common.
Journal Article > Study
Medication safety and knowledge-based functions: a stepwise approach against information overload.
Patapovas A, Dormann H, Sedlmayr B, et al. Br J Clin Pharmacol. 2013;76(supp 1):14-24.
An electronic clinical decision support system for prescribing in the emergency department used tiered alerts with higher and lower urgency information in order to avoid alert fatigue.
Journal Article > Study
Physicians' responses to clinical decision support on an intensive care unit—comparison of four different alerting methods.
Scheepers-Hoeks AMJ, Grouls RJ, Neef C, Ackerman EW, Korsten EH. Artif Intell Med. 2013;59:33-38.
How to tailor warnings within electronic health records to avert safety problems while avoiding alert fatigue is an ongoing question for medical informaticians. This study found that pop-up alerts appeared to be the most effective mechanism for presenting clinical decision support for drug prescribing.
Cases & Commentaries
Electrocardiogram Results: ***READ ME***
- Web M&M
Joseph S. Alpert, MD; November 2012
A woman with new onset chest pain was admitted to the hospital. Although the computer readout of her electrocardiogram stated "***ACUTE MI***" at the top, the nursing assistant who performed the test placed it in the patient's bedside chart without notifying a nurse or physician. The patient was, in fact, having a myocardial infarction, whose treatment was delayed.
Journal Article > Study
Prevalence of medication administration errors in two medical units with automated prescription and dispensing.
Rodriguez-Gonzalez CG, Herranz-Alonso A, Martin-Barbero ML, et al. J Am Med Inform Assoc. 2012;19:72-78.
Technological solutions such as computerized provider order entry (CPOE) hold promise for reducing medication errors at the prescribing and dispensing stage, but patients may still be harmed by incorrect administration of medications, which have been shown to be disturbingly common in prior studies. Conducted at an academic hospital in Spain that had an established CPOE system, this study found an overall administration error rate of 22%, consistent with prior studies. The hospital in question did not have a barcoding medication administration system. Combining barcoding with CPOE in a closed-loop system has been shown to significantly reduce the overall medication error rate.
Journal Article > Study
Automated identification of postoperative complications within an electronic medical record using natural language processing.
- Classic
Murff HJ, FitzHenry F, Matheny ME, et al. JAMA. 2011;306:848-855.
Many adverse event identification methods cannot detect errors until well after the event has occurred, as they rely on screening administrative data or review of the entire chart after discharge. Electronic medical records (EMRs) offer several potential patient safety advantages, such as decision support for averting medication or diagnostic errors. This study, conducted in the Veterans Affairs system, reports on the successful development of algorithms for screening clinicians' notes within EMRs to detect postoperative complications. The algorithms accurately identified a range of postoperative adverse events, with a lower false negative rate than the Patient Safety Indicators. As the accompanying editorial notes, these results extend the patient safety possibilities of EMRs to potentially allow for real time identification of adverse events.
Journal Article > Study
Potential safety gaps in order entry and automated drug alerts: a nationwide survey of VA physician self-reported practices with computerized order entry.
Spina JR, Glassman PA, Simon B, et al. Med Care. 2011;49:904-910.
In contrast to most hospitals and clinics, the Veterans Affairs (VA) health care system has had a fully electronic health record with computerized provider order entry for several years. In this survey, VA physicians generally had positive impressions of the system, with nearly 90% feeling the system improved drug safety and nearly half reporting that serious drug interaction warnings were "very useful." However, the accuracy of drug–drug interaction and allergy warnings within this system are partially dependent upon clinicians manually entering medications prescribed by non-VA providers. As more than one quarter of respondents admitted to not always entering this data, this study highlights the importance of medication reconciliation in establishing accurate medication lists in the ambulatory care setting.
Cases & Commentaries
Milliliters vs. Milligrams
- Web M&M
Robert L. Poole, PharmD; Tessa Dixon, PharmD; December 2010
Following a vehicle collision, a man admitted to the hospital was given a twofold overdose of dexamethasone, due to confusion about administration instructions on a multidose vial.
Journal Article > Study
Measuring the cost of hospital adverse patient safety events.
Carey K, Stefos T. Health Econ. 2011;20:1417-1430.
This analysis of data from the Veterans Affairs system found that the cost of adverse events (as measured by the AHRQ Patient Safety Indicators) is likely much higher than previously estimated.
Journal Article > Study
Comparison of methods for identifying patients at risk of medication-related harm.
van Doormaal JE, Rommers MK, Kosterink JGW, Teepe-Twiss IM, Haaijer-Ruskamp FM, Mol PGM. Qual Saf Health Care. 2010;19:e26.
This study describes the development of decision support algorithms designed to prevent prescribing errors within a computerized provider order entry system. The decision support system was developed and tested in comparison to errors identified by a trained pharmacist.
Journal Article > Study
Computerized decision support for medication dosing in renal insufficiency: a randomized, controlled trial.
Terrell KM, Perkins AJ, Hui SL, Callahan CM, Dexter PR, Miller DK. Ann Emerg Med. 2010;56:623-629.
This study found that adding decision support to an existing computerized provider order entry system reduced the frequency of excessively dosed prescriptions by emergency physicians from 74% to 43%.
Journal Article > Study
Computerized order entry with limited decision support to prevent prescription errors in a PICU.
Kadmon G, Bron-Harlev E, Nahum E, Schiller O, Haski G, Shonfeld T. Pediatrics. 2009;124:945-950.
Hospitalized children are particularly vulnerable to medication errors due to the complexity of weight-based dosing and the resulting potential for calculation errors. Computerized provider order entry (CPOE) has been widely advocated as a means of preventing such errors. In this study, implementation of a CPOE system did not initially reduce adverse drug events in a pediatric intensive care unit. However, when a decision support system for calculating weight-based dosages was added to the CPOE system, medication errors declined significantly. A 2008 Sentinel Event Alert published by The Joint Commission highlighted the prevalence of pediatric medication errors and recommended potential solutions.
Journal Article > Study
Computerized decision support to reduce potentially inappropriate prescribing to older emergency department patients: a randomized, controlled trial.
Terrell KM, Perkins AJ, Dexter PR, Hui SL, Callahan CM, Miller DK. J Am Geriatr Soc. 2009;57:1388-1394.
Elderly patients are particularly vulnerable to adverse drug events. This randomized trial used a decision support system coupled with computerized provider order entry to target prescribing of potentially inappropriate medications to elderly patients in an urban emergency department. Physicians who received alerts warning them of a drug's potential adverse effects were significantly less likely to prescribe potentially harmful medications. Although prior studies of computerized reminders have found that physicians frequently ignore reminders, in this study decision support alerts were accepted nearly half the time, and alerts were generally rejected for valid reasons (for example, the patient had tolerated the medication previously). The challenges of implementing effective medication decision support systems are discussed in an AHRQ WebM&M perspective.
Journal Article > Study
Enhancing pediatric safety: assessing and improving resident competency in life-threatening events with a computer-based interactive resuscitation tool.
Lerner C, Gaca AM, Frush DP, et al. Pediatr Radiol. 2009;39:703-709.
Use of a computerized interactive algorithm significantly improved residents' ability to correctly manage simulated cases of anaphylactic shock.
Journal Article > Study
Systematically improving physician assignment during in-hospital transitions of care by enhancing a preexisting hospital electronic health record.
Zsenits B, Polashenski WA, Sterns RH, Brown DR IV, Moheet A. J Hosp Med. 2009;4:308-312.
An electronic system was developed in order to ensure correct assignment of hospitalist physicians to patients at admission and at the time of care transitions (e.g., discharge from the intensive care unit).
Journal Article > Study
Tiering drug–drug interaction alerts by severity increases compliance rates.
Paterno MD, Maviglia SM, Gorman PN, et al. J Am Med Inform Assoc. 2009;16:40-46.
Customizing drug interaction warnings within a computerized order entry system resulted in fewer clinicians overriding the warnings.
Cases & Commentaries
Recurrent Hypoglycemia: A Care Transition Failure?
- Spotlight Case
- Web M&M
Ted Eytan, MD, MS, MPH; October 2008
An elderly, non–English-speaking man with diabetes was admitted to the hospital twice in 8 days due to hypoglycemia. At discharge, the patient was instructed not to take any antidiabetic medications. In between hospitalizations, he saw his primary care physician, who restarted an antidiabetic medication.
Journal Article > Study
Retrospective evaluation of a computerized physician order entry adaptation to prevent prescribing errors in a pediatric emergency department.
Sard BE, Walsh KE, Doros G, et al. Pediatrics. 2008;122:782-787.
Standardizing care processes, through the use of checklists and other approaches, has been demonstrated to improve patient safety by reducing health care–associated infections and handoff errors. This study implemented a standardized "quicklist" of commonly used pediatric medications within an existing computerized provider order entry system. Although use of the quicklist was not mandatory, prescribing errors were significantly reduced, especially among those providers who used the quicklist regularly. The study provides an example of how standardization combined with decision support can improve medication safety.
Newspaper/Magazine Article
Geisinger Health System's plan to fix America's health care.
Carbonara P. Fast Company. October 2008.
This magazine article describes how one health system is using an evidence-based, pay-for-performance program to reduce errors and improve outcomes in coronary-artery bypass graft (CABG) surgery.
