The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial.

Tinka Bakker; Joanna E Klopotowska; Dave A Dongelmans; Saeid Eslami; Wytze J Vermeijden; Stefaan Hendriks; Julia ten Cate; Attila Karakus; Ilse M Purmer; Sjoerd H W van Bree; Peter E Spronk; Martijn Hoeksema; Evert De Jonge; Nicolette F de Keizer; Ameen Abu-Hanna; Dorieke E.M van Balen; Peter F Schutte; Marnix J Sigtermans; Emile M Kuck; Erik J.M van Kan; Marijke S van der Steen; Liesbeth E Bosma; Ralph O Nowitzky; Albertus Beishuizen; Kris L.L Movig; Elsbeth M Wesselink; Rick J.W Lammers; Cedric Lau; Joost B Masselink; Rob J Bosman; Dylan W de Lange; Rob J van Marum; Heleen van der Sijs; Eric J.F Franssen; Hans Kieft; Walter M van den Bergh; Wouter Bult; Maurits H Renes; Peter W de Feiter; Evert-Jan Wils; Nicole G.M Hunfeld; Froukje Mulder; Michiel Duyvendak

Study

The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial.

February 14, 2024

Bakker T, Klopotowska JE, Dongelmans DA, et al. Lancet. 2024;403(10425):439-449.

View more articles from the same authors.

Alert fatigue occurs when clinical decision support systems (CDSS) produce numerous low-relevance alerts, leading to high override rates and the risk of missing relevant alerts. In this study, alerts for high-risk drug-drug interactions (DDI) were tailored to the intensive care unit. The tailored alerts led to a 12% decrease in high-risk DDI administrations.

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Hospital Pharmacy

Ordering/Prescribing Errors

The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial.

Remote Response Team and Customized Alert Settings Help Improve Management of Sepsis

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