Journal Article

Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals.

Rhee C; Jones TM; Hamad Y; Pande A; Varon J; O'Brien C; Anderson DJ; Warren DK; Dantes RB; Epstein L; Klompas M; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program.

The degree to which sepsis contributes to inpatient mortality and the extent to which sepsis-associated inpatient mortality is preventable remains unknown. In this retrospective cohort study, researchers analyzed the medical records of 568 adult patients hospitalized at 6 United States hospitals who either died during the hospitalization or were discharged to hospice. They found a diagnosis of sepsis was present in 300 cases and that it was the main cause of death in 198 cases. Reviewers rated 11 of the 300 sepsis-associated deaths as definitely or moderately likely preventable. The authors conclude that it may be challenging to further reduce sepsis-associated inpatient mortality.