The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop.

Roger Chou; Judith A. Turner; Emily B. Devine; Ryan N. Hansen; Sean D. Sullivan; Ian Blazina; Tracy Dana; Christina Bougatsos; Richard A. Deyo

Review

The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop.

December 21, 2016

Chou R, Turner JA, Devine EB, et al. Ann Intern Med. 2015;162(4):276-86.

View more articles from the same authors.

Opioid medications are associated with increased risk of adverse drug events, including overdoses. This systematic review found that evidence supporting the use of long-term opioid therapy for chronic pain is lacking.

PubMed citation

Free full text

Related Resources From the Same Author(s)

The impact of computerized provider order entry on medication errors in a multispecialty group practice.

February 3, 2010

Characterization of prescribing errors in an internal medicine clinic.

May 23, 2007

Epidemiology of and risk factors for coronavirus infection in health care workers: a living rapid review.

May 27, 2020

Patterns in nursing home medication errors: disproportionality analysis as a novel method to identify quality improvement opportunities.

December 15, 2010

Evaluation of the quality of 'do not use' medication abbreviation audits: a key enabler to successful implementation of audit and feedback.

March 24, 2021

Serious adverse drug events reported to the FDA: analysis of the FDA Adverse Event Reporting System 2006–2014 database.

October 17, 2018

Why do interns make prescribing errors? A qualitative study.

February 13, 2008

Preventing medication errors in long-term care: results and evaluation of a large scale web-based error reporting system.

August 29, 2007

No shortcuts to safer opioid prescribing.

May 8, 2019

CDC guideline for prescribing opioids for chronic pain—United States, 2016.

March 30, 2016

Reducing high-risk medication use through pharmacist-led interventions in an outpatient setting.

April 8, 2020

Avoiding handover fumbles: a controlled trial of a structured handover tool versus traditional handover methods.

July 11, 2012

Impact of date stamping on patient safety measurement in patients undergoing CABG: experience with the AHRQ Patient Safety Indicators.

October 8, 2008

Medication errors during patient transitions into nursing homes: characteristics and association with patient harm.

January 30, 2005

Communication training, adverse events, and quality measures: 2 retrospective database analyses in Washington State hospitals.

August 9, 2017

Anticoagulant medication errors in nursing homes: characteristics, causes, outcomes, and association with patient harm.

August 7, 2013

Online medication error graphic reports: a pilot in North Carolina nursing homes.

June 15, 2011

Disclosing errors that affect multiple patients.

June 3, 2009

Changes in hospital-acquired conditions and mortality associated with the hospital-acquired condition reduction program.

September 29, 2021

Healthcare staff wellbeing, burnout, and patient safety: a systematic review.

August 24, 2016

Cost-effectiveness of a computerized provider order entry system in improving medication safety ambulatory care.

July 16, 2014

A narrative review of the safety concerns of deprescribing in older adults and strategies to mitigate potential harms.

November 29, 2017

Workarounds in the workplace: a second look.

August 12, 2015

CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022.

November 16, 2022

The World Health Organization '5 moments of hand hygiene': the scientific foundation.

May 23, 2012

Relationship between Leapfrog Safe Practices Survey and outcomes in trauma.

October 26, 2011

Saving lives: a meta-analysis of team training in healthcare.

August 3, 2016

Development of a professionalism committee approach to address unprofessional medical staff behavior at an academic medical center.

April 9, 2014

Hospitalization and death associated with potentially inappropriate medication prescriptions among elderly nursing home residents.

April 15, 2005

Dosing errors made by paramedics during pediatric patient simulations after implementation of a state-wide pediatric drug dosing reference.

July 24, 2019

Repeat medication errors in nursing homes: contributing factors and their association with patient harm.

July 28, 2010

Interpretive diagnostic error reduction in surgical pathology and cytology: guideline from the College of American Pathologists Pathology and Laboratory Quality Center and the Association of Directors of Anatomic and Surgical Pathology.

June 17, 2015

Evaluation of a physician informatics tool to improve patient handoffs.

July 29, 2009

Electronic prescribing reduced prescribing errors in a pediatric renal outpatient clinic.

February 13, 2008

Outcomes after out-of-hospital endotracheal intubation errors.

February 18, 2009

Reducing inappropriate polypharmacy: the process of deprescribing.

April 1, 2015

An analysis of prehospital pediatric medication dosing errors after implementation of a state-wide EMS pediatric drug dosing reference.

March 1, 2023

Efficacy and unintended consequences of hard-stop alerts in electronic health record systems: a systematic review.

October 17, 2018

Persistent next-day effects of excessive alcohol consumption on laparoscopic surgical performance.

May 4, 2011

Scrutinizing incident reporting in anaesthesia: why is an incident perceived as critical?

September 13, 2006

Changes in hospital safety following penalties in the US Hospital Acquired Condition Reduction Program: retrospective cohort study.

July 24, 2019

Hospital readmission after noncardiac surgery: the role of major complications.

March 19, 2014

Patient harm from cardiovascular medications.

August 25, 2021

Medical emergency team implementation: experiences of a mentor hospital.

December 17, 2008

Experience with family activation of rapid response teams.

October 6, 2010

Clinicians' insights on emergency department boarding: an explanatory mixed methods study evaluating patient care and clinician well-being.

August 23, 2023

Patient safety incidents associated with airway devices in critical care: a review of reports to the UK National Patient Safety Agency.

February 18, 2009

The costs of adverse drug events in hospitalized patients.

March 27, 2005

National Patient Safety Foundation agenda for research and development in patient safety.

March 27, 2005

Association between state medical malpractice environment and postoperative outcomes in the United States.

June 21, 2017

Board quality scorecards: measuring improvement.

August 10, 2011

Nighttime and weekend medication error rates in an inpatient pediatric population.

December 15, 2010

Association of coworker reports about unprofessional behavior by surgeons with surgical complications in their patients.

July 10, 2019

Ethical considerations in the development of the Flexibility in Duty Hour Requirements for Surgical Trainees trial.

October 26, 2016

Trigger alerts associated with laboratory abnormalities on identifying potentially preventable adverse drug events in the intensive care unit and general ward.

August 1, 2018

Developing and implementing new safe practices: voluntary adoption through statewide collaboratives.

August 16, 2006

Association of surgical resident wellness with medical errors and patient outcomes.

May 6, 2020

Cognitive engineering to improve patient safety and outcomes in cardiothoracic surgery

December 4, 2019

Incidence of adverse drug events and potential adverse drug events: implications for prevention.

March 27, 2005

The effect of hospitalist discontinuity on adverse events.

March 25, 2015

Clinical predictors for unsafe direct discharge home patients from intensive care units.

October 21, 2020

The value of adding a verbal report to written handoffs on early readmission following prolonged respiratory failure.

December 22, 2010

Review of the Australian Incident Monitoring System.

August 17, 2005

Adopting National Quality Forum medication safe practices: progress and barriers to hospital implementation.

August 22, 2007

Should medical errors be disclosed to pediatric patients? Pediatricians' attitudes toward error disclosure.

September 23, 2015

Pharmacy clarification of prescriptions ordered in primary care: a report from the Applied Strategies for Improving Patient Safety (ASIPS) collaborative.

February 8, 2006

Diagnosis is a team sport—partnering with allied health professionals to reduce diagnostic errors: a case study on the role of a vestibular therapist in diagnosing dizziness.

July 27, 2016

Fall prevention implementation strategies in use at 60 United States hospitals: a descriptive study.

December 9, 2020

Medication error reporting in nursing homes: identifying targets for patient safety improvement.

February 17, 2010

Prevalence and nature of medication administration errors in health care settings: a systematic review of direct observational evidence.

March 27, 2013

Causes of medication administration errors in hospitals: a systematic review of quantitative and qualitative evidence.

September 18, 2013

Understanding the causes of intravenous medication administration errors in hospitals: a qualitative critical incident study.

April 1, 2015

The high cost of low-frequency events: the anatomy and economics of surgical mishaps.

March 27, 2005

Redesigning surgical decision making for high-risk patients.

April 23, 2014

Patient perspectives on test result communication in primary care: a qualitative study.

April 29, 2015

Labeling morphine milligram equivalents on opioid packaging: a potential patient safety intervention.

August 22, 2018

Standardized multidisciplinary protocol improves handover of cardiac surgery patients to the intensive care unit.

June 1, 2011

Does simulation training for acute care nurses improve patient safety outcomes: a systematic review to inform evidence-based practice.

October 23, 2019

COVID-19 pandemic and the tension between the need to act and the need to know.

October 14, 2020

Errors in clinical reasoning: causes and remedial strategies.

June 24, 2009

Discrimination, abuse, harassment, and burnout in surgical residency training.

November 20, 2019

Evaluating sample medications in primary care: a practice-based research network study.

December 6, 2006

Responding to patient safety incidents: the "seven pillars."

April 7, 2010

Efficacy, tolerability, and dose-dependent effects of opioid analgesics for low back pain: a systematic review and meta-analysis.

January 11, 2017

A cognitive forcing tool to mitigate cognitive bias—a randomised control trial.

February 20, 2019

Cognitive bias in clinical medicine.

November 7, 2018

Using standardized OR checklists and creating extended time-out checklists.

October 5, 2016

Failure mode and effects analysis application to critical care medicine.

April 21, 2005

Patient-centered prescription opioid tapering in community outpatients with chronic pain.

March 7, 2018

Near-miss events detected using the emergency department trigger tool.

March 15, 2023

The emergency department trigger tool: a novel approach to screening for quality and safety events.

September 30, 2020

Emergency department adverse events detected using the emergency department trigger tool.

August 24, 2022

Adverse events present on arrival to the emergency department: the ED as a dual safety net.

March 11, 2020

Role of registered nurses in error prevention, discovery and correction.

April 16, 2008

Hospital prescribing of opioids to Medicare beneficiaries.

November 16, 2016

Does standardisation improve post-operative anaesthesia handoffs? Meta-analyses on provider, patient, organisational, and handoff outcomes.

June 1, 2022

A randomized trial of nighttime physician staffing in an intensive care unit.

June 5, 2013

Year in review: medication mishaps in the elderly.

April 27, 2011

Test result communication in primary care: clinical and office staff perspectives.

August 20, 2014

Overrides of medication alerts in ambulatory care.

February 18, 2009

Related Resources

Effect of a Veterans Health Administration mandate to case review patients with opioid prescriptions on mortality among patients with opioid use disorder: a secondary analysis of the STORM randomized control trial.

April 19, 2023

Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed).

March 22, 2023

Impact of opioid administration in the intensive care unit and subsequent use in opioid-naïve patients.

June 9, 2021

A mixed-methods analysis of patient safety incidents involving opioid substitution treatment with methadone or buprenorphine in community-based care in England and Wales.

November 11, 2020

Medicare Part D Beneficiaries at Serious Risk of Opioid Misuse or Overdose: A Closer Look.

May 20, 2020

Strategies to identify patient risks of prescription opioid addiction when initiating opioids for pain: a systematic review.

June 19, 2019

Assessment of the FDA Risk Evaluation and Mitigation Strategy for transmucosal immediate-release fentanyl products.

March 6, 2019

Prevention of prescription opioid misuse and projected overdose deaths in the United States.

February 13, 2019

Effect of genetic diagnosis on patients with previously undiagnosed disease.

November 7, 2018

Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016.

October 10, 2018

Interventions for postsurgical opioid prescribing: a systematic review.

September 19, 2018

Active-shooter response at a health care facility.

September 19, 2018

Characteristics of healthcare organisations struggling to improve quality: results from a systematic review of qualitative studies.

September 5, 2018

Technical rationality and the decentring of patients and care delivery: a critique of 'unavoidable' in the context of patient harm.

July 25, 2018

The burden of opioid-related mortality in the United States.

July 18, 2018

Medication for opioid use disorder after nonfatal opioid overdose and association with mortality: a cohort study.

July 11, 2018

Association of opioid-related adverse drug events with clinical and cost outcomes among surgical patients in a large integrated health care delivery system.

June 20, 2018

Patterns of potential opioid misuse and subsequent adverse outcomes in Medicare, 2008 to 2012.

June 6, 2018

Clinicians' perceptions of medication errors with opioids in cancer and palliative care services: a priority setting report.

May 30, 2018

Physician prescribing of opioids to patients at increased risk of overdose from benzodiazepine use in the United States.

May 16, 2018

Serious incidents after death: content analysis of incidents reported to a national database.

May 16, 2018

A framework for operationalizing risk: a practical approach to patient safety.

May 2, 2018

Opioid Stewardship.

April 25, 2018

Latent risk assessment tool for health care leaders.

April 25, 2018

Attitudes and practices related to clinical alarms: a follow-up survey.

April 18, 2018

Opioid prescribing practices from 2010 through 2015 among dentists in the United States: what do claims data tell us?

April 11, 2018

Hospital Survey on Patient Safety Culture: 2018 User Database Report.

April 4, 2018

Pain states, the opioid epidemic, and the role of radiologists.

April 4, 2018

The other opioid crisis: hospital shortages lead to patient pain, medical errors.

March 28, 2018

Postoperative opioid prescribing: Getting it RIGHTT.

March 21, 2018

See More About The Topic

Hospitals

Facility and Group Administrators

Medicine

Opiates/Narcotics

Epidemiology of Errors and Adverse Events

The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop.

Connect With Us

Sign up for Email Updates

Agency for Healthcare Research and Quality

The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop.

Connect With Us

Sign up for Email Updates

Agency for Healthcare Research and Quality

Submit Your Innovations

Continue as a Guest

Continue Logged In

Submit Your Innovations

Continue as a Guest

Continue logged in

New Users to the PSNet site