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PSNet: Patient Safety Network
Journal Article
Review

The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop.

Chou R, Turner JA, Devine EB, et al. Annals of internal medicine. 2015;162:276-86.

Opioid medications are associated with increased risk of adverse drug events, including overdoses. This systematic review found that evidence supporting the use of long-term opioid therapy for chronic pain is lacking.