The growing use of telehealth can increase patient access to timely care, but also presents patient safety considerations. The use of telehealth to deliver health care services continues to expand. This systematic review included six studies examining safety and quality issues in community pharmacy-based telepharmacy services. Findings suggest that telepharmacies perform similarly or slightly better than traditional pharmacies in terms of medication safety and adherence, but the authors note a high risk of bias amongst the studies which limits the ability to draw definitive conclusions about patient safety and quality-related outcomes.