The I-PASS tool has been implemented in a variety of healthcare settings to improve communication during patient handoffs. This article describes the implementation of an electronic health record (EHR)-based I-PASS tool used to standardize handoff documentation among fellows, residents, advanced practice providers (APPs) and physician assistants (PAs) at one Comprehensive Cancer Center. After I-PASS training, tool adherence improved from 42% to 71% and perceived handoff scores improved on safety culture surveys.