This study sought to develop a tool (PRIME) to predict the risk of post-discharge medication-related harm in older adults. The cohort was derived from inpatients at five hospitals in England and included 119 individuals who experienced medication-related harm requiring healthcare utilization and 699 individuals who did not experience a medication-related harm. Researchers found that the PRIME tool can accurately identify older at-risk patients and may help reduce medication-related harm and subsequent healthcare utilization.