Telemedicine efforts harbor both risk and reward to patients and clinicians. The AHRQ Safety Program for Telemedicine is a national effort to develop and implement bundles of evidence-based interventions designed to improve telemedicine care. To test the bundle of interventions, the latest program will involve a cohort of healthcare professionals who utilize telemedicine in primary care and urgent care clinics to promote appropriate antibiotic prescribing and reduce patient harm. It is an 18-month program beginning in June 2024. Recruitment webinars begin in January and close mid-May 2024.