Journal Article

High-priority drug-drug interaction clinical decision support overrides in a newly implemented commercial computerized provider order-entry system: override appropriateness and adverse drug events.

Edrees H, Amato MG, Wong A, et al. J Am Med Inform Assoc. 2020.

Clinical decision support alerts can notify clinicians to potential prescribing errors and potentially avoid adverse drug events. This retrospective study evaluated over 16,000 alerts for drug-drug interactions and found that nearly 96% were overridden by providers; of these overrides, 45.4% were deemed appropriate upon chart review. Alerts for high-priority drug-drug interactions were overridden 87% of the time, and chart review determined that only 0.5% of these alerts were appropriate. The researchers found that 5.1 adverse drug events occurred per 100 overrides.